Wednesday, September 19th, 2018

Arrival to Arad, Registration (starts at 1400)


16:00 Opening Ceremony
17:00-17:50 Plenary Lecture – Chair: István Krizbai (Hungary)
FRANCISCO RIVERA, Universidad Austral de Chile, Valdivia, Chile
Exploring the vascular niche in remyelination: Do we know
17:50-18:00 Short Break
18:00-19:00 SIGNALLING IN THE CELLS OF THE NEUROVASCULAR UNIT Chairs: Maria Deli (Hungary) and Pierre Couraud (France)
1 XAVIER DECLÈVES, University Paris Descartes, France, TRPV functional role in human brain endothelial cells
2 MALGORZATA BUREK, University of Würzburg, Germany, Protocadherin gamma C3 influences multiple signaling pathways in brain microvascular endothelial cell lines
3 MICHAL TOBOREK, University of Miami, USA, Occludin as a regulatory protein in metabolism of cells of neurovascular unit
19:30 Welcome Reception


Thursday, September 20th, 2018

Oral & Poster Presentations



Chairs: Daniela Virgintino (Italy) and Reiner Haseloff (Germany)

4 CLÉMENCE DELIGNE, Université d’Artois, France, In vitro evaluation of physical and metabolic properties of the human pediatric high-grade glioma blood-tumor barrier and the accessibility of chemotherapeutic drugs to the tumor
5 IMOLA WILHELM, Biological Research Centre of the Hungarian Academy of Sciences in Szeged, Hungary, Interaction of breast cancer cells with the neurovascular unit during brain metastasis formation
6 SYNNØVE NORVOLL MAGNUSSEN, The Arctic University of Norway, Tromsø, Norway, Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains
7 CLAUDINE KIEDA, LOMIT, WIM, Warsaw, Poland and CBM, CNRS, UPR 4301, Orleans, France, Normalization of pathologic angiogenesis in tumors: potential on glioma treatment outcome
8 IGNAZIO de TRIZIO, Bari University Medical School, Italy and Department of Neurosurgery, Neurocenter of Southern Switzerland, Regional Hospital Lugano, Switzerland, Nucleolin is a potential

regulator of glioblastoma neovascularization

10:40-11:00 Coffee Break
11:00-12:20 INFLAMMATORY PROCESSES OF THE NEUROVASCULAR UNIT: IN VITRO STUDIE Chairs: Claus Pietrzik (Germany) and Xavier Decleves (France)
9 MARIANA CASTRO DIAS, University of Bern, Switzerland,
Ultrastructural 3D analysis of T-cell diapedesis across the blood-
brain barrier under physiological flow
10 SIDAR AYDIN, University of Bern, Switzerland, The role of endothelial antigen-presentation in the migration of CD8+Tcells across the blood-brain barrier in neuroinflammation
11 ANNE-CLOÉ VOIRIN, University of Saint-Etienne-Lyon, Inflammatory stress induced by combination of inflammatory molecules leads to a loss of blood brain barrier integrity
12 DAVID ROIG-CARLES, The Open University, UK, Brain endothelial-derived extracellular vesicles modulate cerebrovascular function in inflammation
12:20-13:50 Lunch Break
13:50-14:50 INFLAMMATORY PROCESSES OF THE NEUROVASCULAR UNIT: IN VIVO STUDIES Chairs: Bjorn Bauer (USA) and Imola Wilhelm (Hungary)
13 ZSÓFIA HOYK, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary, P-glycoprotein expressional changes in brain microvessel endothelial cells related to neuroinflammation
14 DÁNIEL PÉTER VARGA, University of Szeged, Szeged, Hungary, Microglia modulate the induction of spreading depolarization and the associated cerebral blood flow response
15 FRANCISKA ERDŐ, Pázmány Péter Catholic University, Hungary, Effect of aging on structure and function of the blood-brain barrier
14:50-15:40 Plenary Lecture – ADAM DÉNES, Institute of Experimental Medicine, Budapest, Hungary Brain inflammation, cerebral perfusion and the BBB: a neuroimmune perspective
15:40-17:15 Poster Presentations and Coffee Break
18:00 Wine Tasting and Dinner (“Pavel Covaci” Botanical Garden and Castle, Macea)


Friday, September 21st, 2018
Oral & Poster Presentations


9:00-12:00 ROLE OF THE BLOOD-BRAIN BARRIER IN PATHOLOGICAL PROCESSES OF THE CNS Chairs: Egle Solito (UK) and Malgorzata Burek (Germany)
16 ALEXANDER MAZURA, University Medical Center of the Johannes Gutenberg-University Mainz, Germany, Proprotein convertase subtilisin/kexin type 9 (PCSK9) acts as a key regulator of Aβ transport across the BBB
17 PIETRA CANDELA, University of Artois, France, Ketone bodies and pro-inflammatory cytokines effects on the human in vitro BBB model
18 YUKI SUZUKI, Hokkaido University, Sapporo, Japan, Newly developed high -throughput screening assay identifies potential drugs to protect blood-brain barrier
19 BJOERN BAUER, University of Kentucky, USA, Novel Therapeutic

Targets to Repair Blood-Brain Barrier Dysfunction in Epilepsy

10:20-10:50 Coffee Break
10:50-12:10 PATHOLOGY OF THE NEUROVACULAR UNIT Chairs: Ingolf Blasig (Germany) and Birger Brodin (Denmark)
20 ATTILA FARKAS, Biological Research Centre of the Hungarian Academy of Sciences in Szeged, Hungary, Vascular changes associated with cortical spreading depolarization: role of potassium waves
21 OXANA SEMYACHKINA-GLUSHKOVSKAYA, Saratov State University, Russia, The interaction between blood-brain barrier and the meningeal lymphatics
22 MIHAELA GHERGHICEANU, Victor Babes National Institute of Pathology and Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, The usefulness of electron microscopy in blood brain barrier investigation
23 NATALIE HUDSON, Trinity College Dublin, Ireland, Aberrant BMAL1 dependent claudin-5 cycling induces geographic atrophy
12:10-13:40 Lunch Break
13:40-14:40 INFECTIONS OF THE CNS AND THE BLOOD BRAIN BARRIER Chairs: Lara Ogunshola (Switzerland) and Michal Toborek (USA)
24 BRANDON J KIM, University of Wisconsin, USA, Brain endothelial cells lose defining phenotypes during bacterial infection
25 MARTIN PALUS, Ceske Budejovice and Veterinary Research Institute, Brno, Czech Republic, BBB role during tick-borne encephalitis development
26 FRUZSINA R. WALTER, Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of
Wisconsin-Madison, Mycobacterium-infected dendritic cells induce
granuloma formation promotes bacterial dissemination through an
in vitro blood-brain barrier model
14:40-15:30 Plenary Lecture – Chair: Anca Hermenean (Romania)
MATTHEW CAMPBELL, Trinity College Dublin, Ireland
Dynamic blood brain barrier regulation in sub-concussive brain
15:30-16-30 Poster Presentations
16:30-16:50 Coffee Break
16:50-17:50 DRUG DELIVERY TO THE BRAIN Chairs: Synnove Magnussen (Norway) and Janina Skipor (Poland)
27 BIRGER BRODIN, University of Copenhagen, Denmark, The cell-penetrating peptide Tat facilitates blood-brain barrier permeation of conjugated peptide-drugs
28 INGOLF BLASIG, Leibniz Research Institute for Molecular Pharmacology (FMP) Berlin, Germany, A novel class of drug enhancers specifically addressing the BBB
29 REINER F. HASELOFF, Leibniz Research Institute of Molecular Pharmacology (FMP) Berlin, Germany, Trictide – a tool for crossing


19:00 Gala Dinner